Lesson 3 — Protein Synthesis


Central Dogma


Read pages 636 - 642

DNA has a very important purpose. It contains all the genetic code needed to build an organism. To build an organism, the information in the DNA has to be used to produce proteins. This lesson considers how DNA is used to synthesize proteins.


 


Proteins are large molecules made of amino acids. The order of the nucleotides in DNA provides the code that determines how the amino acids must be strung together to build a protein. A gene is a sequence of nucleotides on the DNA strand that codes for the production of one or more proteins.

All organisms use  the same basic mechanism to produce protein from its genes. This process is referred to as the "Central Dogma". To express a gene, the genetic information is passed from DNA to RNA to protein. Passing the genetic information from DNA to RNA is called transcription. Translation describes the process of passing the message from RNA to protein. 


DNA vs. RNA


In the previous lesson, you learned the structure of DNA and the four nucleotides found in DNA. RNA structure is very similar to DNA except for the five carbon sugar molecules. RNA is ribonucleoic acid. Instead of deoxyribose sugar, RNA has ribose sugars in its structure.

RNA has four nucleotides, just as DNA does, but instead of thymine, it has uracil. This means cytosine pairs with guanine and adenine pairs with uracil in RNA molecules.

Unlike DNA, RNA is a single stranded molecule, but it comes in two types: messenger RNA (mRNA) and transfer RNA (tRNA).



mRNA molecule: grey = carbon, red = oxygen, blue = nitrogen, orange = phosphorus. Public Domain.
Comparing DNA and RNA

 Deoxyribonucleic Acid (DNA)  Ribonucleic Acid (RNA)
 Structure  Double stranded
 Single stranded
 Nucleotides  Adenine = Thymine
Cytosine = Guanine
 Adenine = Uracil
Cytosine = Guanine
 Sugar  Deoxyribose  Ribose