Module 2
1. Module 2
1.8. Page 6
Module 2—The Endocrine System
Endocrine Glands
In Module 1 you learned about the basic unit of the nervous system—the neuron—and how communication occurs through neural pathways. Now, you will learn about the major glands of the endocrine system and how communication through the use of special chemical messengers called hormones occurs.

Endocrine glands are ductless glands—they do not release their secretions into a duct as exocrine glands do. Instead, endocrine glands secrete their hormones directly into the blood, which acts as the transport medium. As the hormones pass cells, only those cells with special receptors will react to their presence. These cells are called target cells. Lipid-soluble hormones and water-soluble hormones activate their target cells very differently. Hormones interact together and, in many instances, one hormone counteracts the action of a second hormone. Hormones such as these are called antagonistic hormones. This type of action is illustrated in the figure on the right.
Some hormones, called tropic hormones, influence other endocrine glands. They are secreted by the hypothalamus-pituitary complex. These hormones are very important in the control and regulation of the endocrine system. An important example is the gonadotropic hormones, which affect the reproductive organs. You can view the regulatory pathway of tropic hormones in “Figure 13.10” on page 441 of your textbook. You may want to sketch a copy this pathway and store it in your course folder for later reference.
hormone: a circulating chemical messenger that is produced by specialized cells, circulated in the bloodstream, and co-ordinates the various parts of the body by interacting with target cells
endocrine gland: a cell, tissue, or organ that produces secretions that are released directly into the bloodstream; a ductless gland; for example, the thyroid gland
exocrine gland: a cell, tissue, or organ that produces secretions that are moved through ducts or channels; for example, a sweat gland
target cells: cells with specialized receptor structures
When stimulated, these receptor structures cause a response in the target cells.
lipid-soluble hormone: a hormone that is chemically identified as a lipid or steroid, such as testosterone, estrogen, progesterone, or cortisol
water-soluble hormone: a hormone that is chemically identified as either an amino acid or a protein, such as epinephrine, human growth hormone, thyroxine, insulin, and glucagon
antagonistic hormones: two hormones that produce opposite effects
tropic hormone: a hormone that has another endocrine gland as its target cell
gonadotropic hormones: hormones that affect the reproductive organs; also called the gonads
Read
To help you identify the main endocrine glands, read pages 436 to 441 in your textbook. Summarize your readings about the endocrine glands in a chart or concept map with the following sections: “endocrine gland,” “hormone produced by gland,” and “primary effect of the hormone.” Place this chart in your course folder for future reference.
Watch and Listen
To further explore and review these concepts visually, watch the following segments of “The Hypothalamus and Pituitary: The Master Complex”:
- “Endocrine System”
- “Hormones”
You may be required to enter a username and password to access these videos. Contact your teacher for this information.
Self-Check
SC 6. Complete either Choice A or Choice B.
Choice A
This interactive drag-and-drop exercise has two parts.
In the first part of the exercise, match the statement that describes a hormone or the function of a hormone with the appropriate endocrine gland.
In the second part of the interactive exercise, drag the name of the hormone to the gland that produces it.
Choice B
Practise labelling the endocrine glands, identifying the hormones they produce, and describing the main functions of the hormones in the exercise that follows. After you have completed the exercise and checked your answers, file it in your course folder for access when you are studying.
Download the diagram of the endocrine system.
- Label the major endocrine glands numbered 1 through 8 on the diagram.
- List the hormones (the number of hormones to be identified is indicated in brackets) that each gland produces. The ovary and testis will be studied in Unit B. Although the thymus and pineal gland are part of the endocrine system, you are not responsible for studying them for this course.
- Construct and complete a table with the following headings.
Endocrine Gland |
Hormone |
Target Cells |
Primary Function |
Self-Check Answers
Choice B
1. and 2. Your labels of the glands on the diagram and the hormones that the glands produce should be very similar to the ones that follow.
1. hypothalamus: secretes releasing and inhibiting factors/hormones
2a. anterior pituitary gland: secretes human growth hormone; thyroid stimulating hormone (TSH); adrenocorticotropic hormone (ACTH); and follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (The last three hormones will be studied in detail in Unit B.)
2b. posterior pituitary: releases oxytocin (to be studied in detail in Unit B) and antidiuretic hormone (ADH)
3. parathyroid glands: secrete parathormone (PTH)
4. thyroid gland: secretes thyroxine and calcitonin
5. adrenal glands; adrenal cortex secretes cortisol, aldosterone, and gonadotropins (to be studied in Unit B); adrenal medulla secretes epinephrine and norepinephrine
6. islet cells of pancreas; insulin and glucagon
7. ovary secretes estrogen and progesterone (to be studied in Unit B)
8. testis secretes testosterone and inhibin (to be studied in Unit B)
3. Your completed table should look like the following sample.
Endocrine Glands, Their Hormones, Target Cells, and Main Functions
Endocrine Gland |
Hormone |
Target Cells |
Primary Functions |
Hypothalamus |
releasing/inhibiting hormones |
pituitary gland |
regulates secretion by anterior pituitary |
Posterior Pituitary |
antidiuretic hormone (ADH) |
kidney |
increases water reabsorption |
oxytocin |
uterus/breasts |
stimulates contraction of uterus and release of milk by breast glands |
|
Anterior Pituitary |
thyroid stimulating hormone (TSH) |
thyroid gland |
stimulates thyroid gland to secrete thyroxine |
adrenocorticotropic hormone (ACTH) |
adrenal cortex |
stimulates adrenal cortex to secrete cortisol |
|
growth hormone (hGH) |
most cells |
stimulates cell division, growth of bones, and metabolism |
|
follicle stimulating hormone (FSH) |
ovary/testis |
stimulates production of egg and sperm cells |
|
luteinizing hormone (LH) |
ovary/testis |
stimulates production of male and female sex hormones |
|
prolactin |
breast cells |
stimulates milk production |
|
Adrenal Medulla |
epinephrine/norepinephrine |
most cells |
fight-or-flight hormones |
Adrenal Cortex |
cortisol |
most cells |
raises blood glucose and breaks down protein |
aldosterone |
kidney |
increases sodium retention and increases water reabsorption |
|
Parathyroid Glands |
parathormone (PTH) |
bone cells |
stimulates calcium release from bones |
Thyroid Gland |
thyroxine |
most cells |
increases metabolic rate and regulates growth and development |
calcitonin |
bone cells |
stimulates bones to absorb calcium |
|
Pancreas |
insulin |
most cells |
increases permeability of glucose in cells; stimulates liver cells to convert glucose to glycogen |
glucagon |
liver cells |
stimulates release of glucose by converting glycogen to glucose |
|
Ovary |
estrogen |
uterus/other cells |
stimulates growth of uterine lining; stimulates development of female secondary sex characteristics |
progesterone |
uterus |
promotes growth of uterine lining; inhibits uterine contractions during pregnancy |
|
Testes |
testosterone |
testis/other cells |
promotes sperm production; stimulates development of male secondary sex characteristics |
inhibin |
testis |
inhibits sperm production |